1141855-86-8
1141855-86-8 structure
- Name: WYE-151650
- Chemical Name: WYE-151650
- CAS Number: 1141855-86-8
- Molecular Formula: C26H21N5O2
- Molecular Weight: 435.487
- Create Date: 2020-01-20 16:20:57
- Modify Date: 2024-01-05 17:07:14
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WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively; inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes, exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation; inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models.
| Name | WYE-151650 |
|---|
| Description | WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively; inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes, exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation; inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models. |
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| References | References 1. Lin TH, et al. Arthritis Rheum. 2010 Aug;62(8):2283-93. View Related Products by Target JAK |
| Molecular Formula | C26H21N5O2 |
|---|---|
| Molecular Weight | 435.487 |