16961-77-6
16961-77-6 structure
- Name: CPA-7
- Chemical Name: CPA-7
- CAS Number: 16961-77-6
- Molecular Formula: Cl3H6N3O2Pt
- Molecular Weight: 381.501
- Create Date: 2020-01-12 11:42:50
- Modify Date: 2022-11-21 19:56:07
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A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells; selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.
| Name | CPA-7 |
|---|
| Description | A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells; selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors. |
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| References | References 1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42. 2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. 3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804. 4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504. View Related Products by Target STAT |
| Molecular Formula | Cl3H6N3O2Pt |
|---|---|
| Molecular Weight | 381.501 |