1848251-24-0
1848251-24-0 structure
- Name: SirReal2
- Chemical Name: SirReal2
- CAS Number: 1848251-24-0
- Molecular Formula: C22H20N4OS2
- Molecular Weight: 420.549
- Create Date: 2020-01-20 12:39:56
- Modify Date: 2024-02-26 16:28:38
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SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.
| Name | SirReal2 |
|---|
| Description | SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1. |
|---|---|
| References | References 1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263. 2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin |
| Molecular Formula | C22H20N4OS2 |
|---|---|
| Molecular Weight | 420.549 |