2313525-90-3
2313525-90-3 structure
- Name: LEI110(LEI-110
- Chemical Name: LEI110
- CAS Number: 2313525-90-3
- Molecular Formula: C25H23F3N2O3
- Molecular Weight: 456.465
- Catalog: Research Areas Infection
- Create Date: 2020-01-12 11:08:51
- Modify Date: 2024-01-13 18:20:03
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LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT).
| Name | LEI110 |
|---|
| Description | LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT). |
|---|---|
| References | References 1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969. View Related Products by Target Phospholipase |
| Molecular Formula | C25H23F3N2O3 |
|---|---|
| Molecular Weight | 456.465 |