775573-79-0
775573-79-0 structure
- Name: Cathepsin B inhibitor RC1
- Chemical Name: Cathepsin B inhibitor RC1
- CAS Number: 775573-79-0
- Molecular Formula: C20H39NO2
- Molecular Weight: 325.537
- Create Date: 2020-01-11 21:15:33
- Modify Date: 2023-01-12 00:39:47
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Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes; protects host cells independently of LT concentration and also blocks intoxication by other bacterial exotoxins; reduces the pathogenicity of Human cytomegalovirus and HSV-1 (EC50=12 uM), which relies on cathepsin B protease activity.
| Name | Cathepsin B inhibitor RC1 |
|---|
| Description | Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes; protects host cells independently of LT concentration and also blocks intoxication by other bacterial exotoxins; reduces the pathogenicity of Human cytomegalovirus and HSV-1 (EC50=12 uM), which relies on cathepsin B protease activity. |
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| References | References 1. Hartmann S, et al. ACS Infect Dis. 2018 May 18. doi: 10.1021/acsinfecdis.8b00053. 2. Gillespie EJ, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. View Related Products by Target Cathepsin |
| Molecular Formula | C20H39NO2 |
|---|---|
| Molecular Weight | 325.537 |