1895050-66-4
1895050-66-4 structure
- Name: 6RK73
- Chemical Name: 6RK73
- CAS Number: 1895050-66-4
- Molecular Formula: C13H17N5O2S
- Molecular Weight: 307.37
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2020-01-23 17:42:51
- Modify Date: 2024-01-10 13:02:31
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6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].
| Name | 6RK73 |
|---|
| Description | 6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 0.23 µM (UCHL1), 236 µM (UCHL3)[1] |
| In Vitro | 6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells[1]. 6RK73(5 µM; 24-48 hours) results migration significantly slower than the DMSO control group in MDA-MB-436 cells[1]. Cell Viability Assay[1] Cell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 24, 48 hours Result: Migrated significantly slower than the DMSO control group Western Blot Analysis[1] Cell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 1, 2, 3 hours Result: Displayed strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels. |
| In Vivo | 6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish[1]. |
| References |
| Molecular Formula | C13H17N5O2S |
|---|---|
| Molecular Weight | 307.37 |
| Hazard Codes | Xi |
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