787623-60-3

787623-60-3 structure

Name: (Rac)-E1R
Chemical Name: (Rac)-E1R
CAS Number: 787623-60-3
Molecular Formula: C₁₃H₁₆N₂O₂
Molecular Weight: 232.28
Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
Create Date: 2020-01-23 11:27:51
Modify Date: 2024-01-11 09:22:23
(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Name	(Rac)-E1R

Description	(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
In Vitro	Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1].
References	[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.