1779796-36-9

1779796-36-9 structure

Name: MFZ 10-7
Chemical Name: MFZ 10-7 hydrochloride
CAS Number: 1779796-36-9
Molecular Formula: C₁₅H₁₀ClFN₂
Molecular Weight: 272.70
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2020-06-01 14:49:28
Modify Date: 2024-01-10 14:57:35
MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats[1].

Name	MFZ 10-7 hydrochloride

Description	MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5. MFZ 10-7 hydrochloride inhibits cocaine-taking and cocaine-seeking behavior in rats[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	rat mGluR5:0.67 nM (Ki)
In Vitro	MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].
In Vivo	MFZ 10-7 hydrochloride (3 mg/kg, 10 mg/kg; i.p.) inhibits cocaine self-administration in rats[1]. MFZ 10-7 hydrochloride can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1]. Animal Model: Male Long-Evans rats (250-300 g)[1] Dosage: 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection, single injection Result: Dose-dependently shifted the cocaine dose-response curve downward and inhibited cocaine self-administration maintained by a high dose (0.5 mg/kg/infusion) of cocaine.
References	[1]. Thomas M Keck, et al. A Novel mGluR5 Antagonist, MFZ 10-7, Inhibits Cocaine-Taking and Cocaine-Seeking Behavior in Rats. Addict Biol . 2014 Mar;19(2):195-209.

Molecular Formula	C₁₅H₁₀ClFN₂
Molecular Weight	272.70