152815-28-6

152815-28-6 structure

Name: RS-25344 hydrochloride
Chemical Name: RS 25344 hydrochloride
CAS Number: 152815-28-6
Molecular Formula: C₁₉H₁₄ClN₅O₄
Molecular Weight: 411.799
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2021-05-08 00:56:53
Modify Date: 2024-01-14 10:39:11
RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2].

Name	RS 25344 hydrochloride
Synonyms	1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1) Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-(3-nitrophenyl)-3-(4-pyridinylmethyl)-, hydrochloride (1:1) 1-(3-Nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride (1:1)

Description	RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	PDE Ⅳ:0.28 nM (IC50) PDE Ⅰ:>100 μM (IC50) PDE Ⅱ:160 μM (IC50) PDE Ⅲ:330 μM (IC50)
In Vitro	RS-25344 hydrochloride (0-10 μM) is a potent inhibitor of sperm PDE activity, with an effective concentration of 0.3 nM and reaching maximum inhibition in the range of 100 nM[2].
In Vivo	RS-25344 hydrochloride (5 mg/kg; i.p.; twice daily for 72 h) results in significant increases in stomach weights in wild type C57BL/6 mice[3]. RS-25344 hydrochloride (1 mg/kg; i.p.; 30 min prior to food bolus) increases gastric retention in mice[3].
References	[1]. T Kaneko, et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal. 1995 Jul;7(5):527-34. [2]. J D Fisch, et al. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod. 1998 May;13(5):1248-54. [3]. Will McDonough, et al. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. FASEB J. 2020 Sep;34(9):12533-12548.

Molecular Formula	C₁₉H₁₄ClN₅O₄
Molecular Weight	411.799
Exact Mass	411.073425

Hazard Codes	Xi

152815-28-6	143339-12-2
51703-58-3	422511-01-1
1173022-16-6	186002-54-0
168986-61-6	185376-97-0
167710-87-4	300815-41-2
2138245-24-4	2138261-35-3
2229556-00-5	1158522-08-7
2137844-77-8	2229207-98-9
940364-43-2	134104-43-1
131615-57-1	6906-52-1