Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ML254
Price:
Purity: 99.94%
Stocking Period: 10 Day
Contact: Yang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ML254
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: ML 254
Price: ￥Inquiry/100mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

1428630-86-7

1428630-86-7 structure

1428630-86-7 structure

Name: ML254
Chemical Name: ML 254
CAS Number: 1428630-86-7
Molecular Formula: C₁₈H₁₅FN₂O₂
Molecular Weight: 310.32
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2021-05-21 13:15:00
Modify Date: 2024-01-10 19:15:04
ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1].

Name	ML 254

Description	ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	rat mGluR5:9.3 nM (EC50) rat mGluR5:8.03 nM (pEC50)
References	[1]. Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996.

Molecular Formula	C₁₈H₁₅FN₂O₂
Molecular Weight	310.32