1021106-40-0
1021106-40-0 structure
- Name: IXA6
- Chemical Name: IXA6
- CAS Number: 1021106-40-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Cell Cycle/DNA Damage IRE1
- Create Date: 2021-04-06 10:46:38
- Modify Date: 2024-01-10 08:10:22
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IXA6 is a novel IRE1/XBP1s activator, and can induce IRE1 RNase activity[1].
| Name | IXA6 |
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| Description | IXA6 is a novel IRE1/XBP1s activator, and can induce IRE1 RNase activity[1]. |
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| Related Catalog | |
| In Vitro | IXA6 (10 µM; 4 or 18 h) selectively activates IRE1-XBP1s signaling, and activates the XBP1s transcriptional response[1]. IXA6 (10 µM; 4 h) shows selectivity for IRE1-XBP1s-dependent ER proteostasis remodeling[1]. IXA6 (10 µM; 18 h) reduces secretion of APP through IRE1 activation[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 10 µM Incubation Time: 18 hours Result: Increasesd in ER proteostasis factor gene expression correspond to increased protein levels. RT-PCR[1] Cell Line: HEK293T cells Concentration: 10 µM Incubation Time: 4 hours Result: Activated the IRE1-XBP1s geneset to levels about 30-40% that observed for Tg (Tg representing 100% activation of each gene). Cell Viability Assay[1] Cell Line: HEK293T cells Concentration: 10 µM Incubation Time: 4 hours Result: Observed high level of overlap (64%) for genes induced by XBP1s and IXA6. RT-PCR[1] Cell Line: Huh7 and SHSY5Y cells Concentration: 10 µM Incubation Time: 4 hours Result: Upregulated XBP1s mRNA selectively, in cell lines including Huh7 and SHSY5Y cells. RT-PCR[1] Cell Line: CHO cells Concentration: 10 µM Incubation Time: 18 hours Result: Observed reduction in Aβ secretion blocked by cotreatment with 4µ8c, confirming this reduction is dependent on IRE1 RNAse activity in CHO7WD10 cells stably expressing wild-type APP (APPWT) and in cells treated with the IXA6. |
| References |
| No Any Chemical & Physical Properties |