1802013-08-6

1802013-08-6 structure

Name: ITH 12575
Chemical Name: ITH12575
CAS Number: 1802013-08-6
Molecular Formula: C₁₈H₁₈ClNOS
Molecular Weight: 331.860
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2021-09-12 21:17:50
Modify Date: 2024-01-12 12:03:21
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].

Name	ITH12575
Synonyms	7-Chloro-5-(2'-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one 4,1-Benzothiazepin-2(3H)-one, 7-chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]- 7-Chloro-5-(2-isopropylphenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one ITH12575 MFCD30720887

Description	ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
References	[1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. [2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10.