330819-85-7

330819-85-7 structure

Name: VU0029251
Chemical Name: VU0029251
CAS Number: 330819-85-7
Molecular Formula: C₁₀H₁₁N₃S₂
Molecular Weight: 237.344
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2021-09-11 12:48:03
Modify Date: 2024-10-06 19:25:38
VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM)[1].

Name	VU0029251
Synonyms	MFCD00698485 5H-Cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine, 6,7-dihydro-2-(methylthio)- VU0029251 2-(Methylsulfanyl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine 6,7-dihydro-2-(methylthio)-5h-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine

Description	VU0029251 is a mGluR5 partial antagonist (Ki: 1.07 μM). VU0029251 inhibits glutamate induced calcium mobilization in HEK293 cell membranes expressing rat mGluR5 (IC50: 1.7 μM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR5[1].
References	[1]. Rodriguez, A.L., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol. Pharmacol. 78(6), 1105-1123 (2010).