11089-65-9

11089-65-9 structure

Name: Tunicamycin
Chemical Name: tunicamycin
CAS Number: 11089-65-9
Molecular Formula: C₃₉H₆₄N₄O₁₆(n=₁₀)
Molecular Weight: 844.94 (n=10)
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-06-09 15:15:08
Modify Date: 2024-01-02 22:21:25
Tunicamycin is a N-acetylglucosamine containing antibiotic from Streptomyces lysosuperijkus which inhibits protein glycosylation.

Name	tunicamycin
Synonyms	TUNICAMYCIN,STREPTOMYCES LYSOSUPERFICUS MFCD00065709 Tunicamycin Streptomyces sp. (2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2S,3S,4S,5R,6S)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-12-methyl-2-tridecenamide (2E)-N-[(2S,3R,4R,5R,6R)-2-{[(2S,3S,4S,5R,6S)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-6-{(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxyethyl}-4,5-dihydroxytetrahydro-2H-pyran-3-yl]-12-methyltridec-2-enamide (non-preferred name) TUNICAMYCIN

Description	Tunicamycin is a N-acetylglucosamine containing antibiotic from Streptomyces lysosuperijkus which inhibits protein glycosylation.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Inflammation/Immunology
References	[1]. Nami B et al. Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells. Exp Toxicol Pathol. 2016 Aug;68(7):419-26. [2]. Guo Q et al. Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation via PERK-ATF4-CHOP Signaling in a Murine Model of Neutrophilic Asthma. J Asthma. 2016 Jul 6

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 39,1148,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0225 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 80 (estimated) No. of Female Employees: 30 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P264-P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	28
Safety Phrases	28-37/39-45
RIDADR	UN 3462 6
WGK Germany	3
RTECS	YO7980200
Packaging Group	II
Hazard Class	6.1(a)
HS Code	29419090