425642-32-6
425642-32-6 structure
- Name: GLYCEROPHOSPHOINOSITOL CHOLINE
- Chemical Name: GLYCEROPHOSPHOINOSITOL CHOLINE
- CAS Number: 425642-32-6
- Molecular Formula: C14H32NO12P
- Molecular Weight: 437.377
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2021-09-12 20:17:43
- Modify Date: 2024-01-02 16:30:48
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Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].
| Name | GLYCEROPHOSPHOINOSITOL CHOLINE |
|---|---|
| Synonyms |
GLYCEROPHOSPHOINOSITOL CHOLINE
2-Hydroxy-N,N,N-trimethylethanaminium (2R)-2,3-dihydroxypropyl (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl phosphate |
| Description | Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1]. Cell Viability Assay[1] Cell Line: Rat pheochromocytoma cells PC12 Concentration: 0 or 70 μM Incubation Time: 4 days Result: Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM. Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group. |
| In Vivo | Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2]. Animal Model: Postoperative pain model of female C57/Bl6 mice[2] Dosage: 0.2 and 100 mg/kg/h Administration: Subcutaneous injection, 24 or 48 hours Result: Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h. Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours. |
| References |
| Molecular Formula | C14H32NO12P |
|---|---|
| Molecular Weight | 437.377 |
| Exact Mass | 437.166199 |