341944-06-7

341944-06-7 structure

Name: 3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE
Chemical Name: 3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
CAS Number: 341944-06-7
Molecular Formula: C₉H₉ClN₄S
Molecular Weight: 240.713
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2021-09-13 18:46:30
Modify Date: 2024-04-02 17:08:48
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].

Name	3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine
Synonyms	1H-1,2,4-Triazol-5-amine, 3-[[(2-chlorophenyl)methyl]thio]- MFCD00215049 3-[(2-Chlorobenzyl)sulfanyl]-1H-1,2,4-triazol-5-amine 4H-1,2,4-triazol-3-amine, 5-[[(2-chlorophenyl)methyl]thio]- 5-[(2-Chlorobenzyl)sulfanyl]-4H-1,2,4-triazol-3-amine MFCD03847132

Description	Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 15 μM (RpMetAP1)[1]
In Vitro	Antibacterial agent 117 can inhibit RpMetAP1 with an IC50 value of 15 μM[1]. Antibacterial agent 117 (0.3 μM, 3 μM, 30 μM and 300 μM) stimulates endothelial cell (EC) metabolism and also inhibits rickettsial growth[1].
References	[1]. Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem