208109-39-1
208109-39-1 structure
- Name: F13714 fumarate
- Chemical Name: F13714 fumarate
- CAS Number: 208109-39-1
- Molecular Formula: C25H29ClF2N4O5
- Molecular Weight: 538.97
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2021-09-05 13:29:59
- Modify Date: 2024-01-12 16:02:13
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F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].
| Name | F13714 fumarate |
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| Description | F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1]. |
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| Related Catalog | |
| Target |
5-HT1A Receptor |
| In Vitro | F13714 targets 5-HT1A autoreceptors[1]. |
| In Vivo | In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1]. F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats[1]. |
| References |
| Molecular Formula | C25H29ClF2N4O5 |
|---|---|
| Molecular Weight | 538.97 |