2242636-28-6
2242636-28-6 structure
- Name: E7766 disodium
- Chemical Name: E7766 disodium
- CAS Number: 2242636-28-6
- Molecular Formula: C24H26F2N10Na2O8P2S2
- Molecular Weight: 792.58
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2021-11-02 13:18:11
- Modify Date: 2024-01-11 01:07:58
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E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].
| Name | E7766 disodium |
|---|
| Description | E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1]. |
|---|---|
| Related Catalog | |
| In Vitro | E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1]. |
| In Vivo | In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1]. |
| References |
| Molecular Formula | C24H26F2N10Na2O8P2S2 |
|---|---|
| Molecular Weight | 792.58 |