2357107-60-7
2357107-60-7 structure
- Name: Thalidomide-5-propoxyethanamine
- Chemical Name: 5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- CAS Number: 2357107-60-7
- Molecular Formula: C18H21N3O5
- Molecular Weight: 359.38
- Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
- Create Date: 2021-12-19 19:24:59
- Modify Date: 2024-01-16 14:00:54
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Thalidomide-5-propoxyethanamine is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].
| Name | 5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
|---|---|
| Synonyms |
1H-Isoindole-1,3(2H)-dione, 5-[3-(2-aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-
5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Description | Thalidomide-5-propoxyethanamine is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. Mainolfi, Nello, et al. IRAK DEGRADERS AND USES THEREOF. Patent US20190192668A1. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 615.5±55.0 °C at 760 mmHg |
| Molecular Formula | C18H21N3O5 |
| Molecular Weight | 359.38 |
| Flash Point | 326.1±31.5 °C |
| Exact Mass | 359.148132 |
| LogP | 0.45 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.606 |