2222042-47-7
2222042-47-7 structure
- Name: As-358
- Chemical Name: As-358
- CAS Number: 2222042-47-7
- Molecular Formula: C18H31NO2
- Molecular Weight: 293.44
- Catalog: Signaling Pathways Anti-infection Filovirus
- Create Date: 2022-06-11 13:45:38
- Modify Date: 2024-02-01 14:52:55
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As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM[1].
| Name | As-358 |
|---|
| Description | As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 47.5 μM (EBOV), 3.7 μM (MARV)[1] |
| In Vitro | As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1]. As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively. |
| References |
| Molecular Formula | C18H31NO2 |
|---|---|
| Molecular Weight | 293.44 |