2416909-42-5

2416909-42-5 structure

Name: Anti-MRSA agent 3
Chemical Name: Anti-MRSA agent 3
CAS Number: 2416909-42-5
Molecular Formula: C₂₉H₁₈BrN₃O₂
Molecular Weight: 520.38
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-11 21:57:57
Modify Date: 2024-01-15 19:07:32
Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA[1].

Name	Anti-MRSA agent 3

Description	Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 0.098 μg/ml (MRSA)[1]
In Vivo	Anti-MRSA agent 3 has potent efficacy at a dose of 10 mg/kg (20% survival) in a mouse peritonitis model[1].
References	[1]. Wang X, et al. Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. Eur J Med Chem. 2022;230:114099.

Molecular Formula	C₂₉H₁₈BrN₃O₂
Molecular Weight	520.38