2416924-93-9

2416924-93-9 structure

2416924-93-9 structure

Name: EGFR-IN-64
Chemical Name: EGFR-IN-64
CAS Number: 2416924-93-9
Molecular Formula: C₂₀H₂₁N₃O₃
Molecular Weight: 351.40
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2022-08-06 18:42:17
Modify Date: 2024-01-09 19:29:17
EGFR-IN-64 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-64 shows anticancer activity[1].

Name	EGFR-IN-64

Description	EGFR-IN-64 (Compound 3c) is a potent EGFR inhibitor with an IC50 of 0.33 μM. EGFR-IN-64 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.33 μM (IC50)
In Vitro	EGFR-IN-64 (Compound 3c) shows cytotoxicity with IC50 values of 4.46 ± 0.11 μM and 16.23 ± 0.65 μM against MCF-7 and WI-38, respectively[1].
References	[1]. George RF, et al. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg Chem. 2020 Jun;99:103780.

Molecular Formula	C₂₀H₂₁N₃O₃
Molecular Weight	351.40