1351941-69-9
1351941-69-9 structure
- Name: Sacibertinib
- Chemical Name: Sacibertinib
- CAS Number: 1351941-69-9
- Molecular Formula: C32H31ClN6O4
- Molecular Weight: 599.08
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2022-10-20 14:45:29
- Modify Date: 2024-04-09 21:20:27
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Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
| Name | Sacibertinib |
|---|
| Description | Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFR-TK phosphorylation:110 nM (EC50) HER2:244 nM (EC50) |
| In Vitro | Sacibertinib has inhibitory activity against Sk-Br-3, SW620 cells with GI50s of 3.8 nM and 1.78 μM, and against CCRF-CEM/T, Fadu, BxPc-3 and AsPC-1 with IC50s of 5.6 μM, 101 nM, 337 nM and 1 μM, respectively[1]. |
| References |
[1]. Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138) |
| Molecular Formula | C32H31ClN6O4 |
|---|---|
| Molecular Weight | 599.08 |