2056878-75-0

2056878-75-0 structure

Name: Osocimab
Chemical Name: Osocimab
CAS Number: 2056878-75-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2023-02-24 10:57:13
Modify Date: 2024-04-05 21:48:06
Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects[1].

Name	Osocimab

Description	Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
In Vitro	Osocimab (1.4 nM-1 μM；30 分钟) 抑制凝血酶生成，同时抑制人血浆中 FXIa 介导的 FIX 激活 (或 FIX 转化) (IC50=16 nM) 和 FXIa 介导的底物裂解 (IC< sub>50=1.2 nM)[1]。 Osocimab (22.05 mg/mL) 抑制内在通路介导的凝血级联激活[1]。
References	[1]. Schaefer M, et al. Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J Mol Biol. 2019 Dec 6;431(24):4817-4833.

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