2315268-27-8

2315268-27-8 structure
2315268-27-8 structure
  • Name: Nemvaleukin alfa
  • Chemical Name: Nemvaleukin alfa
  • CAS Number: 2315268-27-8
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
  • Create Date: 2023-05-22 12:23:47
  • Modify Date: 2024-07-17 17:23:38
  • Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].

Name Nemvaleukin alfa
Description Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer[1][2][3].
Related Catalog
In Vitro Nemvaleukin alfa 激活食蟹猴和人类样本的淋巴细胞亚群,EC50s 为 0.45-2.2 nM[2]。 Nemvaleukin alfa (0-100 nM,30 分钟) 诱导人细胞 (HH 细胞) 上的中等亲和力 IL-2R 的激活[3]。 Nemvaleukin alfa (0-100 nM,30 分钟) 在 NK 细胞中诱导 pSTAT5,EC50 为 0.45 nM[3]。 Nemvaleukin alfa (0.5 nM,5 天) 诱导从人外周血中分离的效应淋巴细胞的激活[3]。
In Vivo Nemvaleukin alfa (6 mg/kg,皮下注射,每 4 天一次) 抑制小鼠 SCLC 肿瘤的生长[1]。 Animal Model: SCLC orthotopic model[1] Dosage: 6 mg/kg Administration: s.c., every 4 days Result: Delayed tumor growth and prolonged survival. Animal Model: Male cynomolgus monkeys (PK Assay)[2] Dosage: 0.3 or 1 mg/kg Administration: i.v. or s.c. Result: Pharmacokinetic profile of Nemvaleukin alfa. Dose Route dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) i.v. 0.3 6119 0.083 49.5 s.c. 0.3 549 8 61.9 s.c. 1 1035 8 37.3
References

[1]. Pan Y, et al, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer. J Immunother Cancer. 2022 Sep;10(9):e004913.  

[2]. Lopes JE, et al. Pharmacokinetics and Pharmacodynamic Effects of Nemvaleukin Alfa, a Selective Agonist of the Intermediate-Affinity IL-2 Receptor, in Cynomolgus Monkeys. J Pharmacol Exp Ther. 2021 Nov;379(2):203-210.  

[3]. Lopes JE, et al. ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 Apr;8(1):e000673.  

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