2719001-44-0

2719001-44-0 structure

2719001-44-0 structure

Name: STING agonist-31
Chemical Name: STING agonist-31
CAS Number: 2719001-44-0
Molecular Formula: C₄₃H₅₁N₁₅O₆
Molecular Weight: 873.96
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2023-06-10 23:03:17
Modify Date: 2024-01-18 18:04:42
STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].

Name	STING agonist-31

Description	STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> STING
In Vitro	STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING，EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM，24 h) 激活 ISG 信号和 NF-κB 信号[1]。
In Vivo	STING agonist-31 (化合物 40) (10 mg/kg，静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg，静脉注射) 在大鼠中显示出 T1/2：0.697 h，AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth.
References	[1]. Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669.

Molecular Formula	C₄₃H₅₁N₁₅O₆
Molecular Weight	873.96