2151881-74-0

2151881-74-0 structure

Name: SIQ17
Chemical Name: SIQ17
CAS Number: 2151881-74-0
Molecular Formula: C₃₂H₂₇NO₂S
Molecular Weight: 489.63
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-09-29 19:50:30
Modify Date: 2024-03-08 23:07:03
SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research[1]

Name	SIQ17

Description	SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research[1]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Hengphasatporn K,et.al. Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors. ACS Omega. 2023 May 23;8(22):19645-19655.

Molecular Formula	C₃₂H₂₇NO₂S
Molecular Weight	489.63