2768650-56-0
2768650-56-0 structure
- Name: NLRP3-IN-8
- Chemical Name: NLRP3-IN-8
- CAS Number: 2768650-56-0
- Molecular Formula: C23H20N2O6
- Molecular Weight: 420.41
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NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC 50 value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t 1/2 = 138.63 min), and has almost no toxicity (against L02: IC 50 > 100 μM) [1] .
| Name | NLRP3-IN-8 |
|---|
| Description | NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC 50 value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t 1/2 = 138.63 min), and has almost no toxicity (against L02: IC 50 > 100 μM) [1] . |
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| Molecular Formula | C23H20N2O6 |
|---|---|
| Molecular Weight | 420.41 |