2924156-46-5

2924156-46-5 structure

Name: Anti-inflammatory agent 54
Chemical Name: Anti-inflammatory agent 54
CAS Number: 2924156-46-5
Molecular Formula: C₁₇H₁₆N₂O₅
Molecular Weight: 328.32
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2024-04-05 10:51:59
Modify Date: 2024-04-05 10:51:59
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].

Name	Anti-inflammatory agent 54

Description	Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86(8):1950-1959..

Molecular Formula	C₁₇H₁₆N₂O₅
Molecular Weight	328.32