1391936-86-9

1391936-86-9 structure

Name: Azemiopsin
Chemical Name: Azemiopsin
CAS Number: 1391936-86-9
Molecular Formula: C₁₁₈H₁₇₄N₃₈O₂₆
Molecular Weight: 2540.88
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2024-07-17 19:35:28
Modify Date: 2024-07-17 19:35:28
Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR[1].

Name	Azemiopsin

Description	Azemiopsin is a potent nicotinic acetylcholine receptor (nAChR) inhibitor with IC50s of 0.18 μM and 22 μM against T. californica nAChR and human α7 nAChR, respectively. Azemiopsin blocks acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 0.18 μM (T. californica nAChR), 22 μM (Human α7 nAChR), 63 μM (L. stagnalis AChBP), 230 μM (A. californica AChBP)[1]
References	[1]. Utkin YN, et al. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. J Biol Chem. 2012 Aug 3;287(32):27079-86.

Molecular Formula	C₁₁₈H₁₇₄N₃₈O₂₆
Molecular Weight	2540.88