850090-09-4
850090-09-4 structure
- Name: HO-PEG5-CH2CH2COO<sup>t</sup>Bu
- Chemical Name: 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oa te
- CAS Number: 850090-09-4
- Molecular Formula: C17H34O8
- Molecular Weight: 366.44700
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-09-07 09:57:11
- Modify Date: 2024-01-22 14:36:24
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Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oa te |
|---|---|
| Synonyms |
18-Hydroxy-19-norcorticosterone
18-hydroxy-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester 18-OH-19-NC |
| Description | Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C17H34O8 |
|---|---|
| Molecular Weight | 366.44700 |
| Exact Mass | 366.22500 |
| PSA | 92.68000 |
| LogP | 0.79350 |
|
~81%
850090-09-4 |
| Literature: Wosnick, Jordan H.; Mello, Charlene M.; Swager, Timothy M. Journal of the American Chemical Society, 2005 , vol. 127, # 10 p. 3400 - 3405 |
