1049741-81-2
1049741-81-2 structure
- Name: Cyclopropyl[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone hydrochloride
- Chemical Name: Ciproxifan hydrochloride
- CAS Number: 1049741-81-2
- Molecular Formula: C16H19ClN2O2
- Molecular Weight: 306.78700
- Create Date: 2017-06-01 10:21:22
- Modify Date: 2024-01-02 21:24:15
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Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
| Name | Ciproxifan hydrochloride |
|---|---|
| Synonyms | cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone,hydrochloride |
| Molecular Formula | C16H19ClN2O2 |
|---|---|
| Molecular Weight | 306.78700 |
| Exact Mass | 306.11400 |
| PSA | 54.98000 |
| LogP | 3.81600 |
| Storage condition | 2-8°C |
