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943136-39-8

943136-39-8 structure
943136-39-8 structure
  • Name: Chlorahololide D
  • Chemical Name: Chlorahololide D
  • CAS Number: 943136-39-8
  • Molecular Formula: C38H44O11
  • Molecular Weight: 676.749
  • Catalog: Natural product Sesquiter
  • Create Date: 2016-01-14 03:15:14
  • Modify Date: 2024-01-06 14:26:33
  • Chlorahololide D is a potent and selective Potassium Channel blocker with an IC50 value of 2.7 µM. Chlorahololide D is a nature product that could be isolated from the whole plant of Chloranthus holostegius[1].

Name Chlorahololide D
Synonyms [(1aR,1bS,2R,4Z,8aR,9S,9aS,10aR,10bS,10cS,11bS)-7-(Acetoxymethyl)-2,9-dihydroxy-4-(1-methoxy-1-oxo-2-propanylidene)-1b,10b-dimethyl-3,6-dioxo-1,1a,1b,2,3,4,4a,6,8,8a,9,9a,10,10a,10b,10c,11,11b-octadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-9-yl]methyl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, [(1aR,1bS,2R,4Z,8aR,9S,9aS,10aR,10bS,10cS,11bS)-7-[(acetyloxy)methyl]-1,1a,1b,2,3,4,4a,6,8,8a,9,9a,10,10a,10b,10c,11,11b-octadecahydro-2,9-dihydroxy-4-(2-methoxy-1-methyl-2-oxoethylidene)-1b,10b-dimethyl-3,6-dioxocyclopropa[4,5]cyclopropa[4',5']cyclopent[1',2':7,8]acephenanthryleno[10a,10-b]furan-9-yl]methyl ester, (2E)-
Description Chlorahololide D is a potent and selective Potassium Channel blocker with an IC50 value of 2.7 µM. Chlorahololide D is a nature product that could be isolated from the whole plant of Chloranthus holostegius[1].
Related Catalog
References

[1]. Ping YS, et, al. Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb 25;64(9): 2027-34.

Density 1.4±0.1 g/cm3
Boiling Point 833.7±65.0 °C at 760 mmHg
Molecular Formula C38H44O11
Molecular Weight 676.749
Flash Point 259.4±27.8 °C
Exact Mass 676.288391
PSA 162.73000
LogP 3.08
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.630
Hazard Codes Xi