1143-38-0

1143-38-0 structure

Name: Dithranol
Chemical Name: anthralin
CAS Number: 1143-38-0
Molecular Formula: C₁₄H₁₀O₃
Molecular Weight: 226.227
Catalog: API Special medicine Dermatology medication
Create Date: 2018-06-22 16:33:06
Modify Date: 2024-01-02 12:02:39
Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.

Name	anthralin
Synonyms	1,8,9-Trihydroxyanthracene Anthralin Dithranol Cigthranol MFCD00053409 UNII-U8CJK0JH5M Batridol 1,8-Dihydroxy-9(10H)-anthracenone 1,8,9-Anthracenetriol (1,8-Dihydroxy-9(10H)-anthracenone 1,8-dihydroxy-9-anthrone 1,8-Dihydroxyanthracen-9(10H)-one EINECS 214-538-0 9(10H)-Anthracenone, 1,8-dihydroxy- MFCD00001250 1,8-dihydroxy-10H-anthracen-9-one 1,8-dihydro-9,10H-anthracenone Chrysodermol Anthrone,1,8-dihydroxy 1,8-Dihydroxyanthrone

Description	Dithranol is highly effective in the treatment of psoriasis.Target: OthersDithranol accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. In addition Dithranol may act by reducing the elevated levels of cGMP that occurs in psoriasis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. http://en.wikipedia.org/wiki/Dithranol

Density	1.4±0.1 g/cm3
Boiling Point	464.1±45.0 °C at 760 mmHg
Melting Point	178-181 °C(lit.)
Molecular Formula	C₁₄H₁₀O₃
Molecular Weight	226.227
Flash Point	248.6±25.2 °C
Exact Mass	226.062988
PSA	57.53000
LogP	4.16
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.710
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB8927000
HS Code	2914400090

HS Code	2914400090
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%