Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: brotianide
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Purity: 98.0%
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23233-88-7

23233-88-7 structure

23233-88-7 structure

Name: brotianide
Chemical Name: [2-bromo-6-[(4-bromophenyl)carbamothioyl]-4-chlorophenyl] acetate
CAS Number: 23233-88-7
Molecular Formula: C₁₅H₁₀Br₂ClNO₂S
Molecular Weight: 463.57100
Catalog: API Antineoplastic agents Tinic antineoplastic agents
Create Date: 2018-03-04 08:00:00
Modify Date: 2024-01-15 07:22:38

Name	[2-bromo-6-[(4-bromophenyl)carbamothioyl]-4-chlorophenyl] acetate
Synonyms	Brotianida [INN-Spanish] 2-acetoxy-3-bromo-5-chloro-N-(4'-bromophenyl)-thionobenzamide 2-Brom-6-(4-bromphenylthiocarbamoyl)-4-chlorphenylacetat BAY-VA 4059 3,4'-Dibromo-5-chlorothiosalicylanilide acetate (ester) Brotianide Brotianidum [INN-Latin] EINECS 245-505-9 Dirian 2-Acetoxy-3-bromo-5-chloro-N-(p-bromophenyl)-thiobenzamide FB a 4059

Density	1.795g/cm3
Boiling Point	514.1ºC at 760mmHg
Melting Point	181°C
Molecular Formula	C₁₅H₁₀Br₂ClNO₂S
Molecular Weight	463.57100
Flash Point	264.7ºC
Exact Mass	460.84900
PSA	70.42000
LogP	5.65090
Vapour Pressure	1.11E-10mmHg at 25°C
Index of Refraction	1.699

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8230000

CHEMICAL NAME :: Salicylanilide, 3,4'-dibromo-5-chlorothio-, acetate (ester)

CAS REGISTRY NUMBER :: 23233-88-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H10-Br2-Cl-N-O2-S

MOLECULAR WEIGHT :: 463.59

WISWESSER LINE NOTATION :: QVR DG BE FYUS&MR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%