42061-52-9

42061-52-9 structure

42061-52-9 structure

Name: Pumitepa
Chemical Name: Pumitepa
CAS Number: 42061-52-9
Molecular Formula: C₁₂H₁₉N₈OP
Molecular Weight: 322.30600
Create Date: 2018-08-27 23:03:52
Modify Date: 2024-01-17 07:18:56

Name	Pumitepa
Synonyms	<32P>-Fopunic 6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide

Density	1.7g/cm3
Boiling Point	528.7ºC at 760mmHg
Molecular Formula	C₁₂H₁₉N₈OP
Molecular Weight	322.30600
Flash Point	273.5ºC
Exact Mass	322.14200
PSA	91.77000
LogP	0.52930
Index of Refraction	1.828

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ5827000

CHEMICAL NAME :: Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7 H-purin-6-yl)-

CAS REGISTRY NUMBER :: 42061-52-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H19-N8-O-P

MOLECULAR WEIGHT :: 322.36

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

REFERENCE :: BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 102(7),76,1986