Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Marinobufogenin
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-, (3b,5b,15b)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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470-42-8

470-42-8 structure

470-42-8 structure

Name: Marinobufogenin
Chemical Name: Marinobufagenin
CAS Number: 470-42-8
Molecular Formula: C₂₄H₃₂O₅
Molecular Weight: 400.508
Catalog: Research Areas Others
Create Date: 2018-06-11 21:59:23
Modify Date: 2024-01-04 16:58:44
Marinobufogenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma[1].

Name	Marinobufagenin
Synonyms	(3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy- 5beta-Bufa-20,22-dienolide,14,15beta-epoxy-3beta,5-dihydroxy Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-,(3beta,5beta,15beta) Marinobufagenin Marinobufogenin Marinobufagin Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)- MARCINOBUFAGIN 5-hydroxyl-resibufogenin

Description	Marinobufogenin is a strong inhibitor of Na+/K+ ATPase that has been identified in mammalian plasma[1].
Related Catalog	Research Areas >> Others
Target	IC50: Na+/K+ ATPase[1]
References	[1]. Daniel N, et al. Bufodienolides in pig plasma and urine.

Density	1.3±0.1 g/cm3
Boiling Point	589.0±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.508
Flash Point	203.0±23.6 °C
Exact Mass	400.224976
PSA	83.20000
LogP	1.25
Vapour Pressure	0.0±3.7 mmHg at 25°C
Index of Refraction	1.621

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EI2963000

CHEMICAL NAME :: 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy-

CAS REGISTRY NUMBER :: 470-42-8

LAST UPDATED :: 199009

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C24-H32-O5

MOLECULAR WEIGHT :: 400.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2730 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1520 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 556 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963

Hazard Codes	Xi

Precursor 0
DownStream 1
472-26-4