114056-26-7

114056-26-7 structure

Name: (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt
Chemical Name: (2S)-N-[(2R)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-sulfanylidenepropan-2-yl]-2-[[(2S,3R)-3-hydroxy-2-[[(2S,3S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-(1-sulfan
CAS Number: 114056-26-7
Molecular Formula: C₅₄H₇₉N₁₁O₁₃S₂
Molecular Weight: 1154.401
Catalog: Signaling Pathways GPCR/G Protein Oxytocin Receptor
Create Date: 2017-04-01 10:16:10
Modify Date: 2024-01-10 17:44:21
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1].

Name	(2S)-N-[(2R)-1-[(2S)-2-[[(2S)-5-amino-1-[[(2S)-1-amino-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-sulfanylidenepropan-2-yl]-2-[[(2S,3R)-3-hydroxy-2-[[(2S,3S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[2-(1-sulfan
Synonyms	OVTA N-[(1-Sulfanylcyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl-L-tyrosinamide L-Tyrosinamide, N-[2-(1-mercaptocyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl- Ota-vasotocin

Description	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor Research Areas >> Neurological Disease
Target	Oxytocin[1]
In Vivo	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) 抑制大鼠雄性性行为的某些方面[1]。 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) 可有效抑制雄性大鼠交配行为后的痛觉减退[2]。 Animal Model: Adult Long–Evans/Blue-Spruce rats[1] Dosage: 50 ng, 200 ng, and 1 μg Administration: Intra-MPOA (medial preoptic area) injection, 1 μL Result: Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses. Animal Model: Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)[2] Dosage: 100 ng Administration: Intracerebroventricular injection, 1 μL Result: Was effective in reducing pain threshold heightened by copulatory behavior.
References	[1]. Gil M, et al. Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat. Horm Behav. 2011 Apr;59(4):435-43. [2]. Futagami H, et al. Oxytocin mediates copulation-induced hypoalgesia of male rats. Neurosci Lett. 2016 Apr 8;618:122-126.