13027-33-3

13027-33-3 structure

Name: 3β,5α-Dihydroxycholestan-6-one
Chemical Name: 5alpha-cholestan-3beta,5alpha-diol-6-one
CAS Number: 13027-33-3
Molecular Formula: C₂₇H₄₆O₃
Molecular Weight: 418.652
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-02-13 08:00:00
Modify Date: 2024-01-12 08:34:59
5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].

Name	5alpha-cholestan-3beta,5alpha-diol-6-one
Synonyms	CHOLESTANE-6-OXO-3,5-DIOL Cholestan-6-one, 3,5-dihydroxy-, (3β,5α)- (3β,5α)-3,5-Dihydroxycholestan-6-one CHOLESTANE-6-OXO-3BETA,5ALPHA-DIOL 5ALPHA-HYDROXY-6-KETO CHOLESTEROL YS-64 yakkasterone 3β,5α-Dihydroxycholestan-6-one

Description	5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	5α-Hydroxy-6-keto cholesterol (0.01, 0.1, 1, 10 μM) is cytotoxic to cultured 16-HBE cells[1].
References	[1]. Melissa K Pulfer, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem. 2004 Jun 18;279(25):26331-8.