99697-24-2

99697-24-2 structure

Name: 24-Norursodeoxycholic acid
Chemical Name: 24-Norcholan-23-oic acid, 3,7-dihydroxy-, (3α,5β,7β)
CAS Number: 99697-24-2
Molecular Formula: C₂₃H₃₈O₄
Molecular Weight: 378.54500
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-08-15 18:30:09
Modify Date: 2024-01-02 16:43:13
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.

Name	24-Norcholan-23-oic acid, 3,7-dihydroxy-, (3α,5β,7β)
Synonyms	24-norursodeoxycholic acid 3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic acid Norursodeoxycholic acid 24-Norursodeoxycholic acid 24-Nor Ursodeoxycholic Acid

Description	24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels[1].
References	[1]. Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130(2):465-81.