118072-93-8

118072-93-8 structure

Name: Zoledronic acid
Chemical Name: zoledronic acid
CAS Number: 118072-93-8
Molecular Formula: C₅H₁₀N₂O₇P₂
Molecular Weight: 272.090
Catalog: Organic raw materials Organic phosphine compound
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-02 16:58:00
Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

Name	zoledronic acid
Synonyms	zoledronate Zoledronic acid monohydrate P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate acide [1-hydroxy-2-(1H-imidazol-1-yl)éthane-1,1-diyl]bis(phosphonique) hydrogen [1-hydroxy-2-(1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate [1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) Zometa,Zomera,Aclasta and Reclast MFCD00867791 [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid [1-Hydroxy-2-(1H-imidazol-1-yl)ethan-1,1-diyl]bis(phosphonsäure) Zoledronic acid Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid 2-(Imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate

Description	Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
In Vitro	Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].
References	[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6. [2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

22884-10-2

~99%

118072-93-8

Literature: Synthon B.V. Patent: EP2192126 A1, 2010 ; Location in patent: Page/Page column 9 ;

160975-66-6

118072-93-8

Literature: Letters in Drug Design and Discovery, , vol. 9, # 4 p. 345 - 351

827573-10-4

118072-93-8

Literature: Acta Crystallographica Section C: Crystal Structure Communications, , vol. 69, # 3 p. 263 - 266

22884-10-2

7719-12-2

118072-93-8

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 188, # 1-3 p. 39 - 41

1392687-52-3

118072-93-8

Literature: Russian Journal of General Chemistry, , vol. 82, # 6 p. 1178 - 1179,2 Zhurnal Obshchei Khimii, , vol. 82, # 6 p. 1044 - 1045,2

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%