75352-37-3

MOLECULAR FORMULA :

C16-H27-N-O.Cl-H

MOLECULAR WEIGHT :

285.90

WISWESSER LINE NOTATION :

2N2&2OR C1 FY1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

21 ug/kg

TOXIC EFFECTS :

Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - urine volume increased

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

22 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#11949

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

20 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM. Volume(issue)/page/year: 63,485,1939

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

760 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 13,326,1948