- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Delphinidin-3-sambubioside chloride
- Price:
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Delphinidin-3-sambubioside chloride
- Price: ￥4418.0/5mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Delphinidin-3-sambubioside chloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
53158-73-9
53158-73-9 structure
- Name: Delphinidin-3-sambubioside chloride
- Chemical Name: delphinidin 3-O-β-D-sambubioside
- CAS Number: 53158-73-9
- Molecular Formula: C26H29ClO16
- Molecular Weight: 632.95200
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-12-04 16:29:42
- Modify Date: 2024-01-31 21:02:16
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Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L.[1][3].
| Name | delphinidin 3-O-β-D-sambubioside |
|---|---|
| Synonyms |
delphinidin 3-O-beta-D-sambubioside
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3-chromeniumyl 6-O-β-D-x ylopyranosyl-β-D-glucopyranoside chloride |
| Description | Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L.[1][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1]. Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1]. Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1]. Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM[2]. Delphinidin-3-sambubioside chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2]. Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 50, 100, 200 μM Incubation Time: 30 min Result: Suppressed the degradation of IκB, and the phosphorylation of p65. |
| In Vivo | Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS[1]. Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3]. Animal Model: Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿[1]. Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累[3]。 Dosage: 15 μmol/kg Administration: Intraperitoneal injection (i.p.), for 4 days. Result: Reduced the LPS-induced paw thickness. Decreased the edema by 89.3%. Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α. Animal Model: HFD-fed rats[3] Dosage: 30 mg/kg Administration: Oral gavage, daily for eight weeks. Result: Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits. |
| References |
| Molecular Formula | C26H29ClO16 |
|---|---|
| Molecular Weight | 632.95200 |
| Exact Mass | 632.11400 |
| PSA | 275.42000 |
| Storage condition | 20°C |