153190-29-5

153190-29-5 structure

Name: U 74389G maleate
Chemical Name: u-74389g
CAS Number: 153190-29-5
Molecular Formula: C₄₁H₅₄N₆O₆
Molecular Weight: 726.904
Catalog: Research Areas Others
Create Date: 2016-01-24 17:04:02
Modify Date: 2024-01-10 12:38:14
U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].

Name	u-74389g
Synonyms	MFCD01074991 Pregna-1,4,9(11)-triene-3,20-dione, 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-, (2Z)-2-butenedioate (1:1) 21-{4-[2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl]piperazin-1-yl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-but-2-enedioate (1:1) 21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1)

Description	U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages[3]. Cell Viability Assay[3] Cell Line: Peritoneal macrophages Concentration: 12.5, 25 and 50 μM Incubation Time: 24 hours Result: Reduced the nitrite concentrations in the supernatants of LPS-primed macrophages in a dose-dependent manner.
In Vivo	U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change[2]. U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3]. Animal Model: Rat model of trinitrobenzenesulfonic acid-induced colitis[2] Dosage: 10 mg/kg Administration: Intravenous injection; 10 mg/kg; once daily; 6 d Result: Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight. Animal Model: Male Sprague–Dawley rats injected with Lipopolysaccharide[3] Dosage: 15 or 30 mg/kg Administration: Intravenous injection; 15 or 30 mg/kg Result: Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).
References	[1]. A M Perna, et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res. 1996 Jul-Aug;34(1-2):25-31. [2]. Georgios Antonios Margonis, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb;193(2):667-74. [3]. D Altavilla, et al. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. Eur J Pharmacol. 1999 Mar 12;369(1):49-55.

Boiling Point	811.6ºC at 760 mmHg
Molecular Formula	C₄₁H₅₄N₆O₆
Molecular Weight	726.904
Flash Point	444.6ºC
Exact Mass	726.410461
PSA	147.48000
LogP	5.05700
Vapour Pressure	2.12E-26mmHg at 25°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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