16662-46-7

16662-46-7 structure

Name: Gallopamil hydrochloride
Chemical Name: methoxyverapamil hydrochloride
CAS Number: 16662-46-7
Molecular Formula: C₂₈H₄₁ClN₂O₅
Molecular Weight: 521.08900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-06 18:28:46
Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].

Name	methoxyverapamil hydrochloride
Synonyms	D600 GALLOPAMIL GALLOPAMIL HYDROCHLORIDE D600,HCL (S)-Gallopamil (+/-)-METHOXYVERAPAMIL HCL (+/-)-METHOXYVERAPAMIL,HYDROCHLORIDE GALLOPAMIL HCL D 600 HYDROCHLORIDE

Description	Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent[3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	Ca2+
In Vivo	Gallopamil hydrochloride (Methoxyverapamil hydrochloride; i.v.; 0.2 mg/kg; for 5 min) markedly reduces ventricular tachycardia (VT) and totally prevents fibrillation (VF). Gallopamil significantly reduces systolic and diastolic blood pressure measured 5 min after injection without markedly influencing heart rate[3]. Animal Model: Male Wistar rats weighing 290-370 g[3] Dosage: 0.2 mg/kg Administration: i.v.; 5 min Result: Markedly reduced VT and totally prevented VF.
References	[1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. [2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. [3]. Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2(+)-antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18(4):217-21.

Density	1.068g/cm3
Boiling Point	605.9ºC at 760mmHg
Molecular Formula	C₂₈H₄₁ClN₂O₅
Molecular Weight	521.08900
Flash Point	320.2ºC
Exact Mass	520.27000
PSA	73.18000
LogP	5.90368
Storage condition	-20°C

WGK Germany	3

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