Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tepoxalin
Price:
Purity: 99.03%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Tepoxalin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

103475-41-8

103475-41-8 structure

103475-41-8 structure

Name: Tepoxalin
Chemical Name: tepoxalin
CAS Number: 103475-41-8
Molecular Formula: C₂₀H₂₀ClN₃O₃
Molecular Weight: 385.844
Create Date: 2018-03-26 08:00:00
Modify Date: 2024-01-02 14:53:20
Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile[1].

Name	tepoxalin
Synonyms	Zubrin Tepoxalinum [Latin] 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]-N-hydroxy-N-methylpropanamide 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl- 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide Tepoxalin Tepoxalin [USAN:INN] Tepoxaline Tepoxalina [Spanish] Tepoxalina 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide Tepoxaline [French]

Description	Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Argentieri DC, et al. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther. 1994 Dec;271(3):1399-408.

Density	1.3±0.1 g/cm3
Boiling Point	573.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₀ClN₃O₃
Molecular Weight	385.844
Flash Point	300.3±32.9 °C
Exact Mass	385.119324
PSA	67.59000
LogP	3.84
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.610

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8002500

CHEMICAL NAME :: 1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-me thyl-

CAS REGISTRY NUMBER :: 103475-41-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H20-Cl-N3-O3

MOLECULAR WEIGHT :: 385.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1085 mg/kg/31D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7280 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 54600 mg/kg/26W-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 33,38,1996

19501-58-7 structure

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Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

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Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

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Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

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Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

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Literature: Synthesis, , # 1 p. 18 - 20

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Literature: Synthesis, , # 1 p. 18 - 20

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Literature: Journal of Organic Chemistry, , vol. 57, # 24 p. 6662 - 6663

Precursor 6
19501-58-7 111881-78-8 142791-63-7 144192-63-2
114150-42-4 4229-44-1
DownStream 0