305820-75-1
305820-75-1 structure
- Name: PD173952
- Chemical Name: 6-(2,6-dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one
- CAS Number: 305820-75-1
- Molecular Formula: C24H21Cl2N5O2
- Molecular Weight: 482.36200
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-11-30 03:12:38
- Modify Date: 2024-01-17 20:43:15
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PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2].
| Name | 6-(2,6-dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one |
|---|---|
| Synonyms | hms3263e07 |
| Description | PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2]. |
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| Related Catalog | |
| Target |
Lyn:0.3 nM (IC50) Abl:1.7 nM (IC50) Csk:6.6 nM (IC50) Myt1:8.1 nM (Ki) |
| In Vitro | PD173952 (0-1000 nM; 12 h) 以浓度依赖方式抑制 K562 细胞中 p210Bcr-Abl 和 CrkL 的酪氨酸磷酸化[1]。 PD173952 (0.5 μM; 1-4 days) 抑制 K562 细胞活力[1]。 PD173952 (0.5 μM; 24 and 48 h) 诱导 K562 和 MEG-01 细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: K562 cells Concentration: 0, 25, 50, 100, 200, 500 and 1000 nM Incubation Time: 12 h Result: Inhibited tyrosine phosphorylation of p210Bcr-Abl and CrkL. Cell Viability Assay[1] Cell Line: K562 cells Concentration: 0.5 μM Incubation Time: 1-4 days Result: Caused cell death in a time-dependent manner. Western Blot Analysis[1] Cell Line: K562 and MEG-01 cells Concentration: 0.5 μM Incubation Time: 24 and 48 h Result: 85-kDa PARP fragment was detected. |
| References |
| Molecular Formula | C24H21Cl2N5O2 |
|---|---|
| Molecular Weight | 482.36200 |
| Exact Mass | 481.10700 |
| PSA | 75.51000 |
| LogP | 4.36940 |
| RIDADR | NONH for all modes of transport |
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