24192-64-1

24192-64-1 structure

Name: epiyangambin
Chemical Name: 3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
CAS Number: 24192-64-1
Molecular Formula: C₂₄H₃₀O₈
Molecular Weight: 446.49
Catalog: Natural product Lignans
Create Date: 2017-08-12 23:26:07
Modify Date: 2024-01-12 18:46:47
Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].

Name	3,6-bis(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
Synonyms	syringaresinol dimethyl ether lirioresinol B dimethyl ether epiyangambin

Description	Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology
In Vitro	Epiyangambin (0-25 µM; 24 h) 以剂量依赖性方式抑制 SW480 细胞的生长[1]。 Cell Viability Assay[1] Cell Line: SW480 cells Concentration: 0-25 µM Incubation Time: 24 h Result: Caused reductions in cell number in a dose-dependent manner.
In Vivo	Epiyangambin (20 mg/kg) 显著抑制血小板激活因子受体 (PAF) 诱导的大鼠血小板减少症[2]。
References	[1]. Hausott B, et al. Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. J Cancer Res Clin Oncol. 2003 Oct;129(10):569-76. [2]. Castro-Faria-Neto HC, et al. Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. J Lipid Mediat. 1993 May;7(1):1-9.

Hazard Codes	Xi
HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%