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1465-26-5

1465-26-5 structure
1465-26-5 structure

Name Phenylalanine,4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
Synonyms Dl-alanine,3-(p-[bis(2-chloroethyl)amino]phenyl)-,hydrochloride
MELPHALAN raceMic Mixture
4-[bis-(2-chloro-ethyl)-amino]-DL-phenylalanine,hydrochloride
Dl-phenylalanine,4-[bis(2-chloroethyl)amino]-,monohydrochloride
sarcolysine
4-[bis(2-chloroethyl)amino]-DL-phenylalanine monohydrochloride
Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-,hydrochloride,DL
Dl-phenylalanine mustard hydrochloride
Alanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-,monohydrochloride,DL
4-[Bis-(2-chlor-aethyl)-amino]-DL-phenylalanin,Hydrochlorid
Molecular Formula C13H19Cl3N2O2
Molecular Weight 341.66100
Exact Mass 340.05100
PSA 66.56000
LogP 3.42730

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY3980000
CHEMICAL NAME :
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride, DL
CAS REGISTRY NUMBER :
1465-26-5
LAST UPDATED :
199707
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C13-H18-Cl2-N2-O2.Cl-H
MOLECULAR WEIGHT :
341.69
WISWESSER LINE NOTATION :
QVYZ1R DN2G2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16200 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
44600 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
430 ug/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia Blood - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
860 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - leukopenia Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41600 ug/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 mg/m3/2H/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in spleen Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
66 mg/kg/1Y-I
TOXIC EFFECTS :
Blood - changes in spleen Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
1200 umol/L
REFERENCE :
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 92,943,1981
HS Code 2923900090
HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%