3413-72-7

3413-72-7 structure

Name: MTIC
Chemical Name: mtic
CAS Number: 3413-72-7
Molecular Formula: C₅H₈N₆O
Molecular Weight: 168.15700
Catalog: Research Areas Cancer
Create Date: 2017-09-26 08:12:05
Modify Date: 2024-01-02 19:11:41
MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].

Name	mtic
Synonyms	5-Monomethyltriazenoimidazole-4-carboxamide 5-(3-Monomethyl-1-triazeno)imidazole-4-carboxamide (5E)-5-(methylaminohydrazinylidene)imidazole-4-carboxamide 5-(3-Methyl-1-triazeno)imidazole-4-carboxamide 1H-Imidazole-4-carboxamide,5-(3-methyl-1-triazenyl) 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide Imidazole-4-carboxamide,5-(3-methyl-1-triazeno)

Description	MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
References	[1]. Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163.

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

HS Code	2934999090

593-51-1

7008-85-7

3413-72-7

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 665 - 670

Precursor 2
593-51-1 7008-85-7
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%